黄仕强实验室

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个人介绍

　　黄仕强，男，博士学位，中国科学院动物研究所的研究员，博士生导师，中国科学院大学岗位教授，干细胞再生与代谢研究组组长。
　　2008年于普林斯顿大学 Princeton University 获得分子生物学理学学位（最优等荣誉）。2013年于哈佛医学院 Harvard Medical School 获得生物医学博士学位。2013年至2017年担任新加坡基因组研究所 Genome Institute of Singapore 研究组组长。他是开创干细胞代谢领域的青年研究者之一，研究重点涉及干细胞分化与再生过程中所需的代谢变化。他发现，成年哺乳类动物，包括人类体内有一种处于沉睡状态的“青春”基因 Lin28，能通过代谢调控促使多种受创细胞组织重新修复。该成果发表在 Cell（2013），被国际多家主流媒体所报道。2016年，黄仕强研究组在肌肉干细胞代谢与临床肌肉衰减症的研究中取得了突破，成果发表于 Nature Medicine，成为该期刊的封面文章，备受国际媒体关注。其他研究成果也发表在 Science、Cell、Cell Stem Cell、Cell Metabolism、Cell Reports、Genes Dev、Development等杂志上。目前担任期刊Cell Proliferation副编辑。

发表论文

1. Liu TM^#, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N^#. Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports, 2020, 14 (2), 210-225.
2. Xu C, Ooi WF, Qamra A, Tan J, Chua BY, Ho SWT, Das K, Adam Isa ZF, Li Z, Yao X, Yan T, Xing M, Huang KK, Lin JS, Nandi T, Tay ST, Lee MH, Tan ALK, Ong X, Ashktorab H, Smoot D, Li S, Shyh-Chang N, Teh BT, Tan P. HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer. Gut, 2020, 69(2):231-242.
3. Liu T, Shyh-Chang N^#. Oncofetal SALL4-driven tumorigenesis is highly dependent on oxidative phosphorylation, revealing therapeutic opportunities. Gastroenterology, 2019 157(6):1475-1477.
4. Xu YJ, Liu PP, Ng SC, Teng ZQ, Liu CM. Regulatory networks between Polycomb complexes and non-coding RNAs in central nervous system. J Mol Cell Biol, 2019, mjz058.
5. Jiang Z, Guang L, Li L, Shyh-Chang N^#. Putting stem cells on a low-fat diet switches their pluripotent state. Cell Stem Cell, 2019, 25(1):3-5.
6. Li CW, Yu K^#, Shyh-Chang N^#, Li GX, Jiang LJ, Yu SL, Xu LY, Liu RJ, Guo ZJ, Xie HY, Li RR, Ying J, Li K, Li DJ. (2019). Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle, 2019, 10(3):586-600.
7. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N^#. Assessment of different strategies for scalable production and proliferation of human myoblasts. Cell Prolif, 2019, 52(3):e12602.
8. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell, 2019, 10(9):649-667.
9. Usman WM, Pham TC, Kwok YY, Vu LT, Ma V, Peng B, Chan YS, Wei L, Chin SM, Azad A, He AB, Leung AYH, Yang M, Shyh-Chang N, Cho WC, Shi J, Le MTN. Efficient RNA drug delivery using red blood cell extracellular vesicles. Nat Commun, 2018, 9(1):2359.
10. Shyh-Chang N^#. Metabolic changes during cancer cachexia pathogenesis. Adv Exp Med Biol, 2017, 1026:233-249.
11. Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and metabolomic characterization of a mammalian cellular transition from quiescence to proliferation. Cell Rep, 2017, 20(3):721-736.
12. Liu TM, Shyh-Chang N^#. SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol, 2017, 19(5):412-414.
13. Andriani Y, Chua JM, Chua BY, Phang IY, Shyh-Chang N^#, Tan WS^#. Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater, 2017, 57:115-126.
14. Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N^#, Kumar AP^#, Sethi G^#. Molecular targets of ascochlorin and its derivatives for cancer therapy. Adv Protein Chem Struct Biol, 2017, 108:199-225.
15. Shyh-Chang N^#, Ng HH^#. The metabolic programming of stem cells. Genes Dev, 2017, 31(4):336-346.
16. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell, 2016, 166(2):451-467.
17. Zhang WC, Chin TM, Yang H, Nga ME, Lunny DP, Lim EK, Sun LL, Pang YH, Leow YN, Malusay SR, Lim PX, Lee JZ, Tan BJ, Shyh-Chang N, Lim EH, Lim WT, Tan DS, Tan EH, Tai BC, Soo RA, Tam WL, Lim B. Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. Nat Commun, 2016, 7:11702.
18. Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell, 2016, 19(1):66-80.
19. Fukawa T, Yan-Jiang BC, Min-Wen JC, Jun-Hao ET, Huang D, Qian CN, Ong P, Li Z, Chen S, Mak SY, Lim WJ, Kanayama HO, Mohan RE, Wang RR, Lai JH, Chua C, Ong HS, Tan KK, Ho YS, Tan IB^#, Teh BT^#, Shyh-Chang N^#. Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nat Med, 2016, 22(6):666-71.
20. Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI. Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Mol Cell, 2016, 62(1):34-46.
21. Min-Wen JC, Jun-Hao ET, Shyh-Chang N^#. Stem cell mitochondria during aging. Semin Cell Dev Biol, 2016, 52:110-8.
22. Jun-Hao ET, Gupta RR, Shyh-Chang N^#. Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol Metab, 2016, 27(3):132-141.
23. Liu TM^#, Lee EH, Lim B^#, Shyh-Chang N^#. Balancing stem cell self-renewal and differentiation with PLZF. Stem Cells, 2016, 34(2):277-87.
24. Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H. Precise let-7 expression levels balance organ regeneration against tumor suppression. Elife, 2015, 4:e09431.
25. Khaw SL, Min-Wen C, Koh CG^#, Lim B^#, Shyh-Chang N^#. Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Rep, 2015, 12(7):1080-8.
26. Shyh-Chang N, Daley GQ. Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metab, 2015, 21(3):349-50.
27. Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell, 2013, 155(4):778-92.
28. Shyh-Chang N, Daley GQ, Cantley LC. Stem cell metabolism in tissue development and aging. Development, 2013, 140(12):2535-47.
29. Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells, 2013, 31(8):1563-73.
30. Shyh-Chang N, Daley GQ. Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell, 2013, 12(4):395-406.
31. Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature, 2013, 496(7443):101-5.
32. Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science, 2013, 339(6116):222-6.
33. Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell, 2012, 148(1-2):259-72.
34. Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC. Human pluripotent stem cells decouple respiration from energy production. EMBO J, 2011, 30(24):4851-2.
35. Zhu H^*, Shyh-Chang N^*, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell, 2011, 147(1):81-94.
36. Le MT^*, Shyh-Chang N^*, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet, 2011, 7(9):e1002242.
37. Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ. Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet, 2010, 42(7):626-30.
38. Le MT, Teh C^*, Shyh-Chang N^*, Xie H, Zhou B, Korzh V, Lodish HF, Lim B. MicroRNA-125b is a novel negative regulator of p53. Genes Dev, 2009, 23(7):862-76

其它方面介绍

学习和工作经历：

• 2005~2008 学士，普林斯顿大学 (Princeton University)，最优等荣誉学位
• 2009~2013 博士，哈佛医学院 (Harvard Medical School)
• 2013~2015 博士后，新加坡基因研究所 (GIS)
• 2015~2017 研究组长，新加坡基因研究所 (GIS)
• 2017~现在 教授、研究员，中科院动物所计划生育生殖生物学国家重点实验室

研究领域：

　　本课题组致力于肌肉衰老与再生的机制研究。利用骨骼肌等组织做研究模型，我们开展了一系列的干细胞代谢组学分析工作，探讨如何利用代谢原理来调控细胞命运：（1）研究干细胞代谢如何在组织再生中影响干细胞分化，我们用小分子诱导人类多能干细胞定向分化为肌肉肌纤维。（2）研究衰老过程中肌肉衰减综合征发生的机制。我们用人类多能干细胞诱导分化的骨骼肌肌肌纤维来模拟人类肌肉萎缩，研究不同的促炎细胞因子和其他生长因子在老年人肌肉衰减综合征发展过程中的作用机制，以及强化生活方式干预后与肌萎缩相关的循环因子改善健康状况的分子和代谢机制。（3）干细胞如何通过代谢调控以维持组织的自我平衡，以及研究如何利用干细胞代谢的原理来治疗老龄人群及癌症恶病质患者的肌肉衰减综合征等疾病。我们致力于用干细胞代谢和再生医学提高老龄人群的生活质量，以应对老龄化对中国社会的冲击。

成果奖励：

• 2019 获得中国科学院年度创新人物
• 2013 获得Gordon Conference Travel Award
• 2012 获得Travel Award, International Society for Stem Cell Research (ISSCR)
• 2011 获得ISSCR Best Poster Award
• 2010 获得Travel Award, ISSCR

学生和其他工作人员

曹文华 2018级硕士 广东湛江 caowenhua@ioz.ac.cn	陈煜 2018硕士 陕西商洛 377719222@qq.com	广璐 2018级博士 内蒙古包头 guanglu@ioz.ac.cn	蒋宗敏 博士后 云南省保山市 jiangzongmin@ioz.ac.cn
梁坤 2019级硕士 河北省保定市 1414828325@qq.com	刘睿睿 科研助理 山东滨州liuruirui@ioz.ac.cn	刘涛燕 博士后 湖南永州liutaoyan@ioz.ac.cn	刘旭鹏 2019级直博生 山东潍坊 HZAUliuxupeng@163.com
罗兰芳 2018级硕士 贵州遵义 1434818948@qq.com	马诗琳 2018级硕士 河南洛阳mashilin@ioz.ac.cn	马文武 2018级联培硕士 安徽省阜阳619987074@qq.com	苗鹤凡 技术员 河北省廊坊市 826668989@qq.com
王鹏 2018级博士 山西运城 pengpur@163.com	姚子月 2019级硕士 安徽省蚌埠市 1752360459@qq.com	张丽萍 2020级直博生 山东菏泽1913733271@qq.com

学术和业余活动照片