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刘长梅 研究员

干细胞与神经发育疾病

欢迎您的加入干细胞与神经发育疾病研究组！
- 工作人员：刘佩佩，杜洪震
- 博士后：公茂磊
- 学生：徐雅洁，张双峰，代尚昆，唐清源，彭雪琦，钟婉玲，李长平，闫忠泽，王卓，柯金鹏 ，王慧，张玲静，房文静

· 查看刘长梅实验室网页
 

　　大脑是控制与协调躯体活动和职能的器官，是思维与记忆的中心。神经发生是中枢神经系统形成和功能维持的重要过程，是神经系统发育的核心事件，是神经干细胞不断产生新的成熟神经元并与其他神经元建立突触联系的过程，对理解大脑功能的产生、维持和进化等科学问题有着重要意义。很多与认知功能相关的神经系统疾病均与神经发生的异常相关。
　　我们的研究工作主要是利用报告基因、基因敲入、基因敲除或条件性基因敲除小鼠为模式生物，研究调控神经发生有神经再生的分子和细胞机制，揭示相关的神经发育疾病（如自闭症）和认知功能障碍疾病的致病机制，发现新型的相关疾病分子靶标及干预治疗策略，探索干细胞在神经发育、神经损伤及退行性疾病中的修复功能，发展干细胞介导的神经系统疾病的治疗潜能。

研究内容和目标:
1. 组蛋白修饰调控神经发生的分子机制：探索相关组蛋白修饰调控神经干细胞命运维持、自我更新和定向分化的机制；
2. 神经再生的表观遗传调控机制：阐明神经损伤及修复过程中，组蛋白修饰及染色质重塑促进组织细胞再生和组织修复的机制；
3. 从神经发生的角度，探究神经发育疾病、神经损伤及神经退行性疾病的致病机理，发现新型的相关疾病分子靶标及干预治疗策略；
4. 干细胞在神经系统疾病治疗中的转化研究：利用小鼠、大鼠及非人灵长类模型，探索多能干细胞分化来源的神经细胞对神经发育疾病及神经损伤的治疗；利用视神经损伤模型，结合内源激活与外源干细胞移植的方式，重建神经环路，探索干细胞在视神经损伤治疗中的转化研究。

 

代表性发表论文:

  1. Ma JJ, Ju X, Xu RJ, Wang WH, Luo ZP, Liu CM, Zhou FQ, Saijilafu. Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc. J Neurosci. 2019 Nov 13;39(46):9107-9118.
  2. Xi F, Xu RJ, Xu JH, Ma JJ, Wang WH, Liu CM, Yang HL, Meng B, Saijilafu. Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone. J Cell Physiol. 2019 Dec;234(12):23053-23065.
  3. Zhang SF, Gao J, Liu CM#. The Role of Non-Coding RNAs in Neurodevelopmental Disorders. Front Genet. 2019 Nov 20;10:1033.
  4. Yan HL, Sun XW, Wang ZM, Liu PP, Mi TW, Liu C, Wang YY, He XC, Du HZ, Liu CM#, Teng ZQ#. MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice. Front Mol Neurosci. 2019 Oct 30; 12:260.
  5. Xu YJ*, Liu PP*, Ng SC, Teng ZQ, Liu CM#. Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol. 2019 Jul 10. pii: mjz058 (*Co-first author).
  6. Liu C*, Dai SK*, Sun Z, Wang Z, Liu PP, Du HZ, Yu S, Liu CM#, Teng ZQ#. GA-binding protein GABPβ1 is required for the proliferation of neural stem/progenitor cells. Stem Cell Res. 2019 Aug; 39:101501(*Co-first author).
  7. Liu PP*, Xu YJ*, Dai SK, Du HZ, Wang YY, Li XG, Teng ZQ, Liu CM#. Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. Stem Cell Reports. 2019 Jul 9;13(1):115-131(*Co-first author).
  8. Cheng Y*, Wang ZM*, Tan W*, Wang X*, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, et al. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nat Neurosci. 2018 Dec;21(12):1689-1703(*Co-first author).
  9. Duan RS*, Tang GB*, Du HZ*, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM#. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death and Differentiation. 2018 Sep;25(9):1598-1611(*Co-first author).
  10. Liu PP*, Xu YJ*, Teng ZQ, Liu CM#. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. Neuroscientist. 2018 Jun;24(3):208-220(*Co-first author).
  11. Tang GB*, Zeng YQ*, Liu PP*, Mi TW, Zhang SF, Dai SK, Tang QY, Yang L, Xu YJ, Yan HL, Du HZ, Teng ZQ, Zhou FQ, Liu CM#. The histone h3k27 demethylase utx regulates synaptic plasticity and cognitive behaviors in mice. Front Mol Neurosci, 2017, 10:267(*Co-first author).
  12. Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ#, Liu CM#. MiR-203 Interplays with polycomb repressive complexes to regulate the proliferation of neural stem/progenitor cells. Stem Cell Reports. 2017,9(1):190-202.
  13. Li P, Teng ZQ, Liu CM#. Extrinsic and intrinsic regulation of axon regeneration by micrornas after spinal cord injury. Neural Plasticity, 2016:1279051.
  14. Jiang JJ*, Liu CM*, Zhang BY, Wang XW, Zhang M, Saijilafu, Zhang SR, Hall P, Hu YW, Zhou FQ. MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression. Cell Death and Disease. 2015, 6: e1865 (*Co-first author).
  15. Liu CM*, Wang RY*, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev. 2013, 27(13):1473-83(*Co-first author).
  16. Liu CM*, Teng ZQ*, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5):433-44 (*Co-first author).
  17. Saijilafu, Hur EM, Liu CM, Jiao ZX, Xu WL, and Zhou F-Q. PI3K-GSK3 pathway regulates mammalian axon regeneration by induction of Smad1. Nature Communications, 2013, 4:2690.
  18. Guo W, Zhang Li, Christopher DM, Teng ZQ, Fausett SR, Liu CM, George OL, Klingensmith J, Jin P, Zhao X. RNA binding protein FXR2 regulates proliferation and differentiation of adult hippocampal neural stem cells by repressing Noggin expression. Neuron, 2011, 70:924-938.
  19. Liu CM, Teng ZQ, McQuate AL, Jobe EM, Christ CC, Hoyningen-Huene SJ, Reyes MD, Polich ED, Xing Y, Li Y, Guo W, Zhao X. An Epigenetic Feedback Regulatory Loop Involving MicroRNA-195 and MBD1 Governs Neural Stem Cell Differentiation PLoS One. 2013,8(1): e51436.
  20. Cong HL, Sun LQ, Liu C, Tien P. bition of atrogin-1/MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle atrophy in fasting mice. Hum Gene Ther. 2011 Mar;22(3):313-24.
  21. Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008, 283 (41):27644-77652.
  22. Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010, 8;6(4): e1000898.
  23. Liu CM, Zhao XY. MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med. 2009,11 (3):141-152.
  24. Liu CM, Yang Z, Liu CW, Wang R, Tien P, Dale R, Sun LQ. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Ther. 2008, 15 (3):155-160.
  25. Gong H, Liu CM, Liu DP, Liang CC. The role of small RNAs in human diseases: potential troublemaker and therapeutic tools. Med Res Rev. 2005, 25(3):361-381.
  26. Ke XS, Liu CM, Liu DP, Liang CC. MicroRNAs: key participants in gene regulatory networks. Curr Opin Chem Biol. 2003 7(4):516-523.