生命起始于雌性配子-卵母细胞与雄性配子-精子的结合。研究组以小鼠、非人灵长类和临床样本为材料，致力于揭示（1）卵母细胞发生、减数分裂成熟机制；（2）受精机理。

揭示母源因子调控合子H3K27甲基化建立

发现蛋白翻译后修饰调控雌性生育力维持的新机制

研究内容和目标:
研究组主要研究哺乳动物卵母细胞发生、减数分裂成熟机制及受精机理，阐明卵母细胞的质量控制机制及贡献于生命起始的独特机理。我们的研究结果将有助于人类生殖疾病和出生缺陷的预防和治疗。

代表性发表论文:

1. Zhu FY*, Wang LL*, Meng TG*, Wang RL*, Yang ZX*, Cao Y, Zhu GY, Jin Z, Gao LL, Zeng WT, Wang ZB#, Sun QY#, Zhang D#(2021). Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice. Nat Aging （in press）
2. Meng TG*, Zhou Q*, Ma XS*, Liu XY*, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH#, Wang ZB#, Gao SR#, Sun QY#（2020）. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome. Nat Commun. Dec 11;11(1):6354.
3. Meng TG*, Lu X*, Guo L*, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB#, Sun QY# (2019). Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J . Jan;33(1):1179-1187.
4. Hu MW*, Meng TG*, Jiang ZZ, Dong MZ, Schatten H, Xu X, Wang ZB#, Sun QY# (2016). Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet . Dec 8;12(12):e1006513.
5. Wang ZB*, Jiang ZZ, Zhang QH, Hu MW, Huang L, Ou XH, Guo L, Ouyang YC, Hou Y, Brakebusch C, Schatten H, Sun QY# (2013).Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation, but disrupts polarity establishment and cytokinesis in mouse oocyte. Mol Biol Cell  24(24):3832-41.
6. Wang ZB*, Schatten H, Sun QY# (2011).Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging. Physiology  (Bethesda) 26(5):314-25.