周琪研究组博士后招聘启事----干细胞与生殖生物学国家重点实验室

　　中国科学院动物研究所周琪研究组招聘博士后。周琪研究组长期从事体细胞重编程的研究，在胚胎干细胞、诱导多能性干细胞（iPS细胞）、干细胞分化与转分化机制方面开展了大量的工作，拥有完善的发育生物学、胚胎生物学、细胞生物学、分子生物学设施和平台，因工作发展需要，欲招聘博士后1-3名。

　　招聘主要方向：

　　1. 体细胞重编程机理、新技术新方法的研究；

　　2. 基于高通量筛选，研究多能性干细胞多能性调控规律；

　　3. 人胚胎干细胞分化，并利用动物模型开展细胞移植和治疗的研究。

　　应聘条件

　　 1. 发育生物学、干细胞生物学、免疫学、医学等相关领域已获得或将于近期获得博士学位；专业知识扎实。

　　 2. 熟练掌握基本的细胞及分子生物学技术，掌握干细胞培养及诱导分化技术以及在动物胚胎操作，动物模型和行为学方面有实际工作经验者优先考虑；

　　 3. 具有良好的英文文献阅读、写作和口头表达能力，在相关领域以第一作者发表过 SCI 论文，已发表过较高水平的研究论文者优先考虑；

　　 4. 具有较强的独立工作能力，富有责任心和协作精神；

　　 5. 身体健康，能长期稳定工作。

　　招聘方式和待遇

　　 1. 公开招聘，谢绝来电来访，应聘材料恕不退还，单位将予以保密，初筛后由招聘小组面试。

　　 2. 待遇视申请者实际水平和资历参照动物研究所有关规定，待遇从优。

　　联系方式

　　有意者请先将个人简历、代表性论文电子版，以及2位推荐人的联系方式通过电子邮件发送至wangliu@ioz.ac.cn,并请在主题中注明“应聘博士后”。

　　地址：北京市朝阳区北辰西路 1 号院 5 号，中国科学院动物研究所 D315 房间王柳

　　周琪研究组近期代表性论文：

　　 1. Li W#, Guo XJ#, Teng F, Hou XJ, Lv Z, Zhou SY, Bi Y, Wan HF, Feng CJ, Yuan Y, Zhao XY, Wang L, Sha JH*,Zhou Q*. Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. J Mol Cell Biol. doi: jmcb.mjt031.

　　 2. Li W#, Teng F#, Li T, Li X, Zhou Q*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nature Biotechnology. 2013 Aug 8;31(8):684-6.

　　 3. Li TD#, Zhao XY#, Teng F, Li X, Jiang MG, Li W, Wang XP, Wang JL, Liu L, Liu ZH, Wang L, Zhou Q*(2012) Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats. Journal of Genetics and Genomics 39(11):603-60

　　 4. Li W#, Shuai L#, Wan HF#, Dong MZ#, Wang M, Sang LS, Feng CJ, Luo GZ, Li TD, Li X, Wang LB, Zheng QY, Sheng C, Wu HJ, Liu ZH, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature. 490(7420) (2012):407-11.

　　 5. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. (2012) Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein & Cell 3(1):71-79

　　 6. Sheng C^#, Zheng QY^#, Wu JY^#, Xu Z, Sang LS, Wang LB, Guo CL, Zhu WW, Tong M, Liu L, Li W, Liu ZH, Zhao XY, Wang L, Chen ZG*, Zhou Q*. (2012) Generation of dopaminergic neurons directly from mousefibroblasts and fibroblast-derived neural progenitors. Cell Research. 22:769-772

　　 7. Sheng C^#, Zheng QY^#, Wu JY^#, Xu Z, Wang LB, Li W, Zhang HJ, Zhao XY, Liu L, Wang ZW, Guo CL, Wu HJ, Liu ZH, Wang L, He SG, Wang XJ, Chen ZG*, Zhou Q*. (2012) Direct reprogramming of setoli cells into multipotent neural stem cells by defined factors. Cell Research22:208-218.

　　 8. Tong M^#, Lv Z^#, Liu L^#, Zhu H^#, Zheng QY^#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng FY, Wang L, Wang XJ, Sha JH*, Zhou Q*. (2011) Mice generated from tetraploid complementation competent iPS cells showsimilar developmental features as those from ES cells but are prone totumorigenesis. Cell Research21:1634-1637

　　 9. Niu YY^#, Yu Y^#, Bernat A^#, Yang SH, He XC, Guo XY, Chen DL, Chen YC, Ji SH, Si W, Lv YQ, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu XM, Afanassieff M, Savatier P*, Zhang K*, Zhou Q*, Ji WZ*. (2010) Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. ProcNatlAcadSci USA. 107:17663-7

　　 10. Dai XP^#, Hao J^#, Hou XJ^#, HAI T, Fan Y, YU Y, Jouneau A, Wang L,Zhou Q*. (2010) Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J Biol Chem.

　　 11. Liu L^#, Luo GZ^#, Yang W^#, Zhao X^#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells.J Biol Chem. 285, 19483-19490.

　　 12. Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng FY*, Zhou Q*. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461(7260):86-90.

　　 13. Dai X, Hao J, Zhou Q*. (2009) A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos. Reproduction 138(2):301-308.

　　 14. Yu Y^#, Wu JD^#, Fan Y, Lv Z, Guo XJ, Zhao C, Zhou R, Zhang Z, Wang FQ, Xiao M, Chen L, Zhu H, Chen W, Lin M, Liu JY, Zhou ZM, Wang L, Huo H*, Zhou Q*, Sha JH. (2009) Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Mol Cell Proteomics 8(7):1490-1500.

　　 15. Zhou Q, Renard JP*, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. (2003) Generation of fertile cloned rats by regulating oocyte activation. Science 302(5648):1179.

　　 16. Zhou Q, Boulanger L, Renard JP*. (2000) A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. Cloning2(1):35-44.

　　实验室详细信息：http://sourcedb.ioz.cas.cn/zw/zjrc/200907/t20090716_2088445.html


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