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王红梅实验室

个人介绍 | 承担项目 | 发表论文 | 其它方面介绍 | 实验平台 | 学生和其他工作人员 | 学术和业余活动照片 | 人才培养

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个人介绍

王红梅，博士，研究员，博士生导师；中国科学院动物研究所副所长，中国科学院动物研究所干细胞与生殖生物学国家重点实验室主任，北京干细胞与再生医学研究院副院长。国家杰出青年基金获得者，万人计划领军人才，国家百千万人才工程 “有突出贡献中青年专家”，国家自然科学基金重大项目、创新研究群体项目负责人，中国科学院战略性科技专项先导B课题负责人，国家重点研发计划“基于干细胞的生育力维持与重建”项目负责人。

1995年于北京师范大学生物系获得学士学位，2002年于中国科学院动物研究所获得理学博士学位，2003-2005年在加拿大渥太华健康研究所从事博士后研究。王红梅课题组研究方向包括：（1）哺乳动物早期胚胎和胎盘发育；（2）干细胞与生育力的维持和重建。曾获第十六届谈家桢生命科学创新奖，第五届全国妇幼健康科学技术奖自然科学一等奖，国家人口和计划生育委员会优秀科技成果一等奖，教育部科技进步二等奖等，中国科学院优秀导师奖，“朱李月华优秀教师奖”、“领雁银奖、振翅奖”。近年培养研究生获中国科学院大学国家奖学金；中华人民共和国教育部，博士研究生国家奖学金；中国科学院院长特别奖；中国科学院大学“三好学生”荣誉称号、“优秀毕业生”荣誉称号。目前担任剑桥大学胎盘研究中心学术委员会委员，担任Cell Prolif、Cell Rep Med、Biol Reprod、Reproduction等期刊副主编或编委。在Science、Nature、Cell、Nat Genet等期刊发表论文110余篇，相关工作被Science亮点评价，在Nature网页头条报道，登上Cell期刊封面，入选Nat Methods年度方法，2023中国生命科学十大进展。

发表论文

  1. Yu D, Luo L, Wang H*, and Shyh-Chang N*. Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. Trends in endocrinology and metabolism. 2024.
  2. Yu X, Wu H, Su J, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H*, Wang YL*, and Shyh-Chang N*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell stem cell. 2024, 07.003.
  3. Xu Y, Zhai J, Wu H, and Wang H*. In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis. Nature protocols. 2024.
  4. Wu H, Zhai J, and Wang H*. Unraveling the function of FGF signaling in human hypoblast specialization. Cell Stem Cell. 2024, 31, 945-946.
  5. Xia S, Yu D, Wang Y, He B, Rong Y, Chen R, Xiao Z, Wang H, Wu H*, Yan L*. ISRIB facilitates the co-culture of human trophoblast stem cells and embryonic stem cells. Cell Proliferation. 2024, 57(6): e13599.
  6. Xiao Z, Cui L, Yuan Y, He N, Xie X, Lin S, Yang X, Zhang X, Shi P, Wei Z, Li, Y, Wang H, Wang X, Wei Y, Guo J, Yu L. 3D reconstruction of a gastrulating human embryo. Cell. 2024, 187, 2855-2874.e2819.
  7. Zhao F, Yan L, Zhao X, Wu J, Fang Y, Xin Z, Wang H*, Yang X*. Aberrantly high FBXO31 impairs oocyte quality in premature ovarian insufficiency. Aging and Disease. 2024, 15(2):1-20.
  8. Yu D, Wan H, Tong C, Guang L, Chen G, Su J, Zhang L, Wang Y, Xiao Z, Zhai J, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W*, Qi H*, Wang H*, Shyh-Chang N*. A multi-tissue metabolome atlas of primate pregnancy. Cell. 2024, 187, 764-781.e14.
  9. Wang M, Liu Y, Sun R, Liu F, Li J, Yan L, Zhang J, Xie X, Li D, Wang Y, Li S, Zhu X, Li R*, Lu F*, Xiao Z*, Wang H*. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. Nat Genet. 2024, 56, 294-305.
  10. Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H*, Kim BYS*, Jiang W*. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nat Nanotechnol. 2024,19, 255-263.
  11. Wu, H., Wang, Y., and Wang, H*. Generation of Human Trophoblast Stem Cell-Dependent Placental In Vitro Models. Methods Mol Biol. 2024, 2767, 43-52.
  12. Wu, H., Wang, Y., and Wang, H*. Workflow for Performing Genetic Manipulation in Human Trophoblast Stem Cells Using CRISPR/Cas9 Technology. Methods Mol Biol. 2024, 2767, 53-62.
  13. Wu X, Zhai J, Li Q, Wang H*. The in vitro culture of mammalian embryos. Nat Method. 2023, 20, 1855-1858.
  14. Wu H, Huang XY, Sun MX, Wang Y, Zhou HY, Tian Y, He BJ, Wu AP, Wang H*, Qin CF*. Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids. Nat Commun. 2023, 14, 5541.
  15. Zhai J, Xu Y, Wan H, Yan R, Guo J, Skory R, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W*, Guo F*, Plachta N*, Wang H*. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell. 2023, 186(10), 2078-2091.e18.
  16. Jiang X , Zhai J, Xiao Z, Wu X, Zhang D, Wan H, Xu Y, Qi L, Wang M, Yu D, Liu Y, Wu H, Sun R, Xia S, Yu K, Guo J, Wang H*. Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta spanning during pregnancy at single-cell resolution. Dev Cell. 2023, 58, 806-821.
  17. Wu X, Zhao W, Wu H, Zhang Q, Wang Y, Yu K, Zhai J, Mo F, Wang M, Li S, Zhu X, Liang X, Hu B, Liu GH, Wu J##, Wang H##, Guo F*, Yu L*. An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Prolif. 2023, e13492.
  18. Jiang X*, Wang Y, Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X*, Wang H*. A differentiation roadmap of murine placentation at single-cell resolution. Cell Discov. 2023, 9(1), 30.
  19. Yan R, Cheng X, Gu C, Xu YH, Long X, Zhai JL, Sun FY, Qian JJ, Du YR, Wang H*, Guo F*, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023, 55(1), 130-143.
  20. Wu H, Luo CX, Rong Y, Yu RX, Zhao Y, Yan L*, Wang H*, Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level. Life Medicine. 2023, 2(3): 8.
  21. Zhou J, Jiang X, Wu H, Zhang L, Chen M, Chen M, Shen Z, Guo X*, Wang H*, and Gao F*. Dissecting the fate of Foxl2-expressing cells in fetal ovary using lineage tracing and single-cell transcriptomics. Cell discovery. 2022, 8, 139.
  22. Zhai J, Guo J, Wan H, Qi L, Liu L, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X*, Guo F*, Wu J*, Wang H*. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022, 612(7941), 732-738.
  23. Ma J, Liu Y, Guo Z, Sun R, Yang X, Zheng W, Ma Y, Rong Y, Wang H*, Yang H*, Xiao Z*. The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing. Front Cell Dev Biol. 2022, 10, 1044198.
  24. Chen M, Long X, Chen M, Hao F, Kang J, Wang N, Wang Y, Wang M, Gao Y, Zhou M, Duo L, Zhe X, He J, Ren B, Zhang Y, Liu B, Li J, Zhang Q, Yan L, Cui X, Wang Y##, Gui Y##, Wang H##, Zhu L*, Liu D*, Guo F*, Gao F*. Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans. Cell Rep. 2022, Nov, 41(5):111587.
  25. Gu Z, Guo J, Zhai J, Feng G, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L,Hua H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S*, Wang H*, Gu Q*. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci. 2022, 9(28), e2202282.
  26. Tu W, Ni D, Yang H, Zhao F, Yang C, Zhao X, Guo Z, Yu K, Wang J, Hu Z, Chen Z, Zhao Y, Wang Z, Gao F, Yan L*, Yang X*, Zhu L*, Wang H*. Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study. Sci Bull. 2022, 67(18), 1854-1859.
  27. Li Q, Wu H, Wang Y, Wang H*, Current understanding in deciphering trophoblast cell differentiation during human placentation. Biol Reprod. 2022, 107(1), 317-326.
  28. Wang Y, Jiang X, Jia L, Wu X, Wu H, Wang Y, Li Q, Yu R, Wang H*, Xiao Z*, Liang X*. A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization. Front Cell Dev Biol. 2022, 10, 835445.
  29. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G##, Cao G##, Zhao G##, Wang H##, Zhou Q##, Belmonte JCI##, Qu J*, Zhang W*, Liu GH*. Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging. Dev Cell. 2022, 57(11):1347-1368.e12.
  30. Wu D, Liu Y, Chen W, Shao J, Zhuoma P, Zhao D, Yu Y, Liu T, Yu R, Gan Y, Yu zheng B, Huang Y, Zhang H, Bi X, Tao C, Lai, S, Luo Q, Zhang D, Wang H, Zhaxi P, Zhang J, Qiao J, Zeng C. How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization. Mol Biol Evol. 2022, 39.
  31. Yan L, Wang H*. Ketone bodies determine the female reproductive lifespan via regulating the ovarian reserve. Life Metab. 2022, 101-102.
  32. Wang Y, Wu H, Jiang X, Jia L, Wang M, Rong Y, Chen S, Wang Y, Xiao Z*, Liang X*, Wang H*. LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells. Front Cell Dev Biol. 2022, 10, 836390.
  33. Long X, Yang Q, Qian J, Yao H, Yan R, Cheng X, Zhang Q, Gu C##, Gao F##, Wang H##, Zhang L*, Guo F*. Obesity modulates cell-cell interactions during ovarian folliculogenesis. iScience. 2021, 25(1), 103627.
  34. Zhai J, Xiao Z, Wang Y, Wang H*. Human embryonic development: from peri-implantation to gastrulation. Trends Cell Biol. 2022, 32(1), 18-29.
  35. Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao G, G, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J, Zhang W, Liu G, H, Bian X, W. A single-cell transcriptomic landscape of the lungs of patients with COVID-19. Nature cell biology. 2021, 23, 1314-1328.
  36. Qu Y, Chen Q, Guo S, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan *E, Zhang Y*, Wang H*. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein Cell. 2021, 12(10), 810-817.
  37. Yan R, Gu C, You D, Huang Z, Qian J, Yang Q, Cheng X, Zhang L##, Wang H##, Wang P*, Guo F*. Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing. Cell Stem Cell. 2021, 28(9), 1641-1656.e7.
  38. Wu H, Liao S*, Wang Y, Guo M, Lin X, Wu J, Wang R, Lv D, Wu D, He M, Hu B, Long R, Peng J, Yang H, Yin H, Wang X, Huang Z, Lan K, Zhou Y, Zhang W, Xiao Z, Zhao Y*, Deng D*, Wang H*. Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19. Cell Prolif. 2021, 54(9), e13091.
  39. Liang G, Zhou C, Jiang X, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B*, Wang H*, Han JJ*, Liu F*. De novo generation of macrophage from placenta-derived hemogenic endothelium. Dev Cell. 2021, 56(14), 2121-2133.
  40. Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao ZA, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W*, Li L*. Author Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Res. 2022, 32(9):866.
  41. Li X, Wang Y, Ma R, Liu X, Song B, Duan Y, Guo J, Feng G, Cui T, Wang L, Hao J*, Wang H*, Gu Q*. Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCsin vivoandin vitro. Biomed Mater. 2021, 16(3), 035023.
  42. Yan L, Wu Y, Li L, Wu J, Zhao F, Gao Z, Liu W, Li T, Fan Y*, Hao J*, Liu J*, Wang H*. Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Prolif. 2020, 53(12), e12938.
  43. Cui D, Liu Y, Jiang X, Ding C, Poon LC*, Wang H*, Yang H*. Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta. Ultrasound Obstet Gynecol. 2021, 57(2), 248-256.
  44. Xiao Z, Yan L, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Curr Opin Cell Biol. 2020, 67, 86-91.
  45. Zhao Y, Ma J, Yi P, Wu J, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J*, Wang H*, Yan L*. Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice. Stem Cell Res Ther. 2020, 11(1), 466.
  46. Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N*. Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020, 585(7825), 404-409.
  47. Jiang X*, Wang H*. Macrophage subsets at the maternal-fetal interface. Cell Mol Immunol. 2020, 17(8), 889-891.
  48. Gao H, Liu C, Wu B, Cui H, Zhao Y, Duan Y, Gao F*, Gu Q*, Wang H*, and Li W*. Effects of Different Biomaterials and Cellular Status on Testicular Cell Self-Organization. Adv Biosyst. 2020, 4(7), e1900292.
  49. Ma H, Wang H*, Zheng P*, Li L*. Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation'. J Mol Cell Biol. 2020, 12(5), 400-402.
  50. Hong L, Yan L, Xin Z, Hao J, Liu W, Wang S, Liao S, Wang H*, Yang X*. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2020, 12(5), 372-385.
  51. Guo S, Cui X, Jiang X, Duo S, Li S, Gao F*, Wang H*. Tracing the origin of the placental trophoblast cells in mouse embryo development. Biol Reprod. 2020, 102(3), 598-606.
  52. Gu Z, Guo J, Wang H, Wen Y*, Gu Q*. Bioengineered microenvironment to culture early embryos. Cell Prolif. 2020, 53(2), e12754.
  53. Wang R, Yu R, Zhu C, Lin HY, Lu X*, Wang H*. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019, 11(11), 967-978.
  54. Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng
  55. P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019, 366(6467).
  56. Tao Y, Tartia A, Lawson M, Zelinski MB, Wu W, Liu JY, Smitz J, Léveillé MC, Leader A, Wang H, Ramsay T, Liu XJ*. Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women? J Assist Reprod Genet. 2019, 36(3), 395-402.
  57. Cao C, Zhang Y, Jia Q, Wang X, Zheng Q, Zhang H, Song R, Li Y, Luo A, Hong Q, Qin G, Yao J, Zhang N, Wang Y, Wang H, Zhou Q, Zhao J*. An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs. Dis Model Mech. 2019, 12(1), dmm036616.
  58. Ma J, Wu J, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic plate under serum-free condition. Stem Cell Res Ther. 2019, 10(1), 19.
  59. Jiang Y, Yan L, Xia L, Lu X, Zhu W, Ding D, Du M, Zhang D, Wang H*, Hu B*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem. 2018, 293(50), 19317-19329.
  60. Jiang X, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cell Mol Immunol. 2018, 15(12), 1027-1037.
  61. Liu Y, Fan X, Wang R, Lu X, Dang YL, Wang H, Lin HY, Zhu C, Ge H, Cross JC*, Wang H*. Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 2018, 28(8), 819-832.
  62. Wang Y, Wang H*. Successful derivation of human trophoblast stem cells. Biol Reprod. 2018, 99(2), 271-272.
  63. Chang WL, Liu YW, Dang YL, Jiang XX, Xu H, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng W*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018, 145(2), dev148932.
  64. Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi G, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H, Liu F, Zhao J*. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017, 130(20), 2161-2170.
  65. Hai T, Guo W, Yao J, Cao C, Luo A, Qi M, Wang X, Wang X, Huang J, Zhang Y, Zhang H, Wang D, Shang H, Hong Q, Zhang R, Jia Q, Zheng Q, Qin G, Li Y, Zhang T, Jin W, Chen ZY, Wang H, Zhou Q, Meng A, Wei H*, Yang S*, Zhao J*. Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis. Human Genetics. 2017, 136(11-12), 1463-1475.
  66. Lu X, Wang R, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Rep. 2017, 21(5), 1150-1159.
  67. Yan L, Li Y, Shi Z, Lu X, Ma J, Hu B, Jiao J*, Wang H*. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem. 2017, 292(31), 12959-12970.
  68. Zhang Y, Wang Q, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends in Molecular Medicine. 2017, 23(7), 604–614.
  69. Liu D, Mo G, Tao Y, Wang H*, Liu XJ*. Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts. Reprod Fertil Dev. 2017, 29(7), 1392-1400.
  70. Hai T, Cao C, Shang H, Guo W, Mu Y, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017, (6), e26248.
  71. Meng TG, Hu MW, Ma XS, Huang L, Liang QX, Yuan Y, Hou Y, Wang H, Schatten H, Wang ZB*, Sun QY*. Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice. Cell Death Dis. 2017, 8(6), e2846.
  72. Jia Q, Cao C, Tang H, Zhang Y, Zheng Q, Wang X, Zhang R, Wang X, Luo A, Wei H, Meng A, Zhou Q*, Wang H*, Zhao J*. A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs. J Genet Genomics. 2017, 44, 215-217.
  73. Lu X, Wang Y, Yan L, Wang L, Li W, Wang H*. Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs. J Genet Genomics. 2016, 43(10), 609-612.
  74. Zheng R, Li Y, Sun H, Lu X, Sun BF, Wang R, Cui L, Zhu C, Lin HY*, Wang H. Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion. Reproduction. 2017, REP-16-0343.
  75. Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L, Wang H, Chen D, Sun Q. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun. 2016, 7:11848.
  76. Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Migr. 2016, 10(1-2), 39-55.
  77. Lu X, He Y, Zhu C, Wang H, Chen S*, Lin HY*. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta. 2016, 39, 45-54.
  78. Wang X, Cao C, Huang J, Yao J, Hai T, Zheng Q, Wang X, Zhang H, Qin G, Cheng J, Wang Y, Yuan Z, Zhou Q, Wang H*, Zhao J*. One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system. Sci Rep. 2016, 6:20620.
  79. Nie M, Yu S, Peng S, Fang Y, Wang H*, Yang X*. miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5. Biol Reprod. 2015, 93(4), 98, 1-10.
  80. Wang X, Zhou J, Cao C, Huang J, Hai T, Wang Y, Zheng Q, Zhang H, Qin G, Miao X, Wang H, Cao S*, Zhou Q*, Zhao J*. Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs. Sci Rep. 2015, 5, 13348.
  81. Tao Y, Liu D, Mo G, Wang H, Liu XJ. Peri-ovulatory putrescine supplementation reduces embryo resorption in older mice. Hum Reprod. 2015, 30(8):1867-1875.
  82. Lei JH, Yang X, Peng S, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab. 2015, 100(5), 1819-27.
  83. Li Y, Zheng R, Wang R, Lu X, Zhu C, Lin HY, Wang H, Yu X*, Fu J*. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction. 2015, 149(4), 339-46.
  84. Zhang Q, Yu S, Huang X, Tan Y, Zhu C, Wang Y, Wang H, Lin H, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 2015, 150(2), 139-149.
  85. Li S, Wang Y, Cao B, Wu Y, Ji L, Li YX, Liu M, Zhao Y, Qiao J, Wang H, Wang H, Han C, Wang YL. Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26. J Clin Endocrinol Metab. 2014, 99(11): E2277-2287.
  86. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang Y, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res. 2014, 24(8):925-42.
  87. Wang R, Dang YL, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod. 2014, 90(6), 117, 1-10.
  88. Wessels JM, Wu L, Leyland NA, Wang H, Foster WG. The brain-uterus connection: brain derived neurotrophic factor (BDNF) and its receptor (Ntrk2) are conserved in the mammalian uterus. PloS one. 2014, 9(4): e94036.
  89. Liu D, Shao H, Wang H, Liu XJ. Meiosis I in Xenopus oocytes is not error-prone despite lacking spindle assembly checkpoint. Cell cycle. 2014, 13(10):1602-1606.
  90. Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F, Gao S, Wang H. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod. 2014, 90(3):52.
  91. Chang WL, Yang Q, Zhang H, Lin HY, Zhou Z, Lu X, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction. 2014, 148(4), 343-352.
  92. Zhou Z, Wang R, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta. 2014, 35(11), 907-18. Placenta.
  93. Li W, Liu D, Chang W, Lu X, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis. 2014, 5(1), e1025.
  94. Zhang S, Lin H, Kong S, Wang S, Wang H, Wang H, Armant DR. Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 2013, 34(5):939-980.
  95. Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone G, Cross JC, Wang H. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS biol. 2013, 11(4):e1001536.
  96. Aguilar PS, Baylies MK, Fleissner A, Helming L, Inoue N, Podbilewicz B*, Wang H*, Wong M*. Genetic basis of cell–cell fusion mechanisms. Trends Genet. 2013, 29(7), 427-437.
  97. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis. 2013, 4(4), e593.
  98. Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis. 2013, 4(2), e502.
  99. Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W*, Wang H*. Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. PLoS One. 2013, 8(2), e50479.
  100. Zhao KQ, Lin HY, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem. 2012, 113(10), 3266-3275.
  101. Wu L, Zhou H, Lin H, Qi J, Zhu C, Gao Z*, Wang H*. Circulating microRNAs are elevated in plasma from severe preeclamptic pregnancies. Reproduction. 2012,143(3):389-397.
  102. Liu Z, Liu H, Fang W, Yang Y, Wang H, Peng J. Insulin-like growth factor binding protein 7 modulates estrogen-induced trophoblast proliferation and invasion in HTR-8 and JEG-3 cells. Cell Biochem Biophys. 2012, 63(1):73-84.
  103. Lin HY, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab. 2012, 97(4), E678-E686.
  104. Yang X, Zhou Y, Peng S, Wu L, Lin HY, Wang S*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction. 2012, 144(2), 235-244.
  105. Qiu Q, Bell M, Lu X, Yan X, Rodger M, Walker M, Wen SW, Bainbridge S, Wang H, Gruslin A*. Significance of IGFBP-4 in the Development of Fetal Growth Restriction. J Clin Endocrinol Metab, 2012, 97, E1429–E1439.
  106. Li Y, Wu L, Lei J, Zhu C, Wang H, Yu X*, Lin H*. Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci, 2012, 55(8), 699-708.
  107. Lin P, Fu J, Zhao B, Lin F, Zou H, Liu L, Zhu C, Wang H*, Yu X*. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol Biol Rep. 2011, 38(3), 1741–1747.
  108. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem. 2010, 285(14), 10870-10879.
  109. Zhang B, Zhou Z, Lin H, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol. 2009, 132(2), 169-179.
  110. Yin J, Wang H, Racey P, Zhang S. Distribution and ultrastructure of Merkel cell of the fishing bat (Myotis ricketti). Sci China C Life Sci. 2009, 52(9):802-806.
  111. Yang Q, Chen SP, Zhang XP, Wang H, Zhu C, Lin HY. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem. 2009, 57(6):605-612.
  112. Fu JJ, Lin P, Lv XY, Yan XJ, Wang HX, Zhu C, Tsang BK, Yu XG*, Wang H*. Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion. Placenta, 2009, 30(4), 305-312.
  113. Zhang X, Zhu C, Lin H, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod. 2007, 77(2), 358-364.
  114. Zhang H, Li Q, Lin H, Yang Q, Wang H, Zhu C. Role of PPARgamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro. Neuro Endocrinol Lett. 2007, 28(3):289-294.
  115. Yang Q, Lin H, Wang H, Zhang H, Zhang X, Wang H, Zhu C. Expression of Smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy. J Histochem Cytochem. 2007, 55(5):453-460.
  116. Craig J, Orisaka M, Wang H, Orisaka S, Thompson W, Zhu C, Kotsuji F, Tsang BK. Gonadotropin and intra-ovarian signals regulating follicle development and atresia: the delicate balance between life and death. Front Biosci. 2007, 12, 3628-3639.
  117. Wang H#, Tsang BK*. Nodal signalling and apoptosis. Reproduction. 2007, 133(5), 847-853.
  118. Yang Q, Wang H, Zhao Y, Lin H, Zhang H, Wang H, Sang Q, Zhu C. Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sci. 2006, 78(24):2804-2811.
  119. 117. Wang H, Wang H, Lin H, Yang Q, Zhang H, Tsang BK, Zhu C. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol. 2006, 206(3):616-623.
  120. Liu G, Zhang X, Lin H, Wang H, Li Q, Ni J, Zhu C. Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and -9. Biochem Biophys Res Commun. 2006, 343(3):832-838.
  121. Lin H, Zhang H, Yang Q, Wang H, Wang H, Chai K, Chen L, Zhu C. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Histochem Cytochem. 2006, 54(10):1139-1147.
  122. Lin H, Yang Q, Wang H, Qi JG, Zhang H, Wang H, Tsang BK, Zhu C. Involvement of SMAD4, but not of SMAD2, in transforming growth factor-beta1-induced trophoblast expression of matrix metalloproteinase-2. Front Biosci. 2006, 11:637-646.
  123. Lin H, Qian D, Zhang X, Liu G, Wang H, Zhu C. Gene expression of transforming growth factor-beta receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Life Sci. 2006, 78(23):2669-2675.
  124. Wang H#, Jiang JY, Zhu C, Peng C, Tsang BK*. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol Endocrinol. 2006, 20(10), 2469-82.
  125. Wang H, Zhao Y, Wang H, Yang Q, Lin H, Sang Q, Zhu C. Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Mol Hum Reprod. 2005, 11(6):429-435.
  126. Liu G, Zhang X, Lin H, Li Q, Wang H, Ni J, Amy Sang QX, Zhu C. Expression of matrix metalloproteinase-26 (MMP-26) mRNA in mouse uterus during the estrous cycle and early pregnancy. Life Sci. 2005, 77(26):3355-3365.
  127. Wang H, Wang H, Li Q, Lin H, Qian D, Zhu C. Expression of proteasome subunits low molecular mass polypeptide (LMP) 2 and LMP7 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Biol Reprod. 2004,71(4):1317-1324.
  128. Qian D, Lin H, Wang H, Zhang X, Liu D, Li Q, Zhu C. Normoxic induction of the hypoxic-inducible factor-1 alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells. Biol Reprod. 2004, 70(6):1822-1827.
  129. Qian D, Lin H, Wang H, Zhang X, Liu D, Li Q, Zhu C. Involvement of ERK1/2 pathway in TGF-beta1-induced VEGF secretion in normal human cytotrophoblast cells. Mol Reprod Dev. 2004, 68(2):198-204.
  130. Lin H, Wang H, Li Q, Liu D, Zhang X, Liu G, Qian D, Zhu C. Expression of Smad2 and Smad4, transforming growth factor-beta signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci. 2004, 80(3-4):303-316.
  131. Wang H, Li Q, Lin H, Yu X, Qian D, Dai J, Duan E, Zhu C. Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Mol Reprod Dev. 2003, 65(2):123-131.
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  133. Li Q, Illman SA, Wang H, Liu DL, Lohi J, Zhu C. Matrix metalloproteinase-28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy. Mol Hum Reprod. 2003, 9(4):205-211.
  134. Li Q, Wang H, Lin H, Liu D, Zhang X, Liu G, Qian D, Zhu C. Expression of gelatinases and their tissue inhibitors in rat corpus luteum during pregnancy and postpartum. Mol Reprod Dev. 2002, 63(3):273-281.
  135. Li Q, Wang H, Zhao Y, Lin H, Sang QA, Zhu C. Identification and specific expression of matrix metalloproteinase-26 in rhesus monkey endometrium during early pregnancy. Mol Hum Reprod. 2002, 8(10):934-940.
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其它方面介绍

主要学习经历：

  • 1999.09～2002.06 中国科学院动物研究所生理学博士
  • 1995.09～1998.07 北京师范大学生物系细胞生物学硕士
  • 1991.09～1995.07 北京师范大学生物系生物学学士

主要工作经历：

  • 2024.10～ 中国科学院动物研究所 副所长
  • 2020.07～  中国科学院动物研究所所务委员
  • 2019.10～2020.08 中国科学院动物研究所所长助理
  • 2018.02～  中国科学院动物研究所党委委员
  • 2017.09～ 干细胞与生殖生物学国家重点实验室主任
  • 2011.01～2017.08 干细胞与生殖生物学国家重点实验室副主任
  • 2013.01～2020.09 干细胞与生殖生物学国家重点实验室党总支书记
  • 2006.09～ 干细胞与生殖生物学国家重点实验室研究员、博士生导师、生殖生理学研究组组长
  • 2003.12～2005.12 加拿大渥太华健康研究所(OHRI)博士后
  • 2003.01～2006.09 计划生育生殖生物学国家重点实验室 副研究员
  • 2002.01～2002.12 计划生育生殖生物学国家重点实验室 助理研究员
  • 1998.07～2002.01 中国科学院动物研究所计划生育生殖生物学国家重点实验室 研究实习员

社会任职：

  • Cell Stem Cell advisory board委员 （2024-）
  • Developmental Cell advisory board委员 （2024-）
  • Centre for Trophoblast Research, Cambridge, Scientific advisory board委员 （2023-）
  • Reproduction 副主编 （2022-）
  • 国际干细胞学会（ISSCR）会员（2021-）
  • Cell Reports Medicine编委（2020-）
  • Cell Proliferation 编委会委员（2018-）
  • Biology of Reproduction 编委会委员（2013-）
  • 动物学杂志 第十三届编辑委员会副主编（2021）
  • Fundamental Research（双月刊） 编委（2021.01-2023.12）
  • 生物医学转化 第一届编委会委员（2020-）
  • 中国生物物理学会女科学家分会（BSC女科学家分会）副秘书长（2021-）
  • 中国动物学会生殖生物学分会 主任委员（2019-）
  • 美国生殖生物学学会（Society for the Study of Reproduction）会员（2001-）

获奖及荣誉：

  • 2023年入选“中国生命科学十大进展”；
  • 2023年第十六届谈家桢生命科学创新奖；
  • 2023年获中国细胞生物学学会干细胞生物学分会，干细胞研究创新科学家奖；
  • 2023年第五届妇幼健康科学技术奖自然科学奖一等奖：（2023-Z-F-7-01）早期胚胎发育与不良妊娠结局；
  • 2023年中国实验动物学会科学技术奖一等奖：（20201004-1-P1403）利用ENU诱变方法大规模创制小型猪突变模型；
  • 2021年中国科学院大学教学科研工作“领雁银奖、振翅奖”；
  • 2020年“中国科学院朱李月华优秀教师奖”；
  • 2020年度中国科学院优秀导师奖；
  • 2017年全国妇幼健康科学技术奖二等奖：（自然科学奖，2017-B-F-04-03）微小RNA对卵泡生长发育的调控及其在卵巢早衰中的作用研究；
  • 2017年全国妇幼健康科学技术奖二等奖：（自然科学奖，2017-B-D-01-02）母胎免疫耐受与排斥（流产）转换的分子机理；
  • 2011年国家人口和计划生育委员会优秀科技成果奖一等奖（2011-01-D01）胚胎植入的分子基础与相关疾病；
  • 2008年教育部高等学校科学研究优秀成果奖（科学技术）二等奖（自然科学类）蝙蝠的行为、进化及其与病毒相互关系的研究；

学生和其他工作人员

学术和业余活动照片

人才培养

张晓萍 (2007届博士) 美国俄亥俄州立大学 (Ohio State University)
付杰军 (2008届博士) 美国芭芭拉．安卡马纳司癌症中心(The Barbara Ann Karmanos Cancer Institute, Detroit, USA)，现在广西医科大学
张保华 (2009届博士) 加拿大渥太华大学健康研究所 (University of Ottawa)
李　闯 (2010届硕士) 攻读博士学位
周　智 (2011届博士) 日本国立遗传学研究所 (Mammalian Development Laboratory, National Institute of Genetics)
吴　亮 (2011届博士) 浙江大学；博士后
赵坤庆 (2012届博士) 北京生命科学院；博士后
王  蕊 (2015届博士) MD安德森癌症中心（The University of Texas MD Anderson Cancer Center）
吕晓寅（2015届博士）MD安德森癌症中心（The University of Texas MD Anderson Cancer Center）
刘丹丹 (2015届博士) 北京大学第三医院；博士后
刘素梅 (2014届硕士) 中国科学院遗传与发育生物学研究所
郑  茹 (2017届博士) 安诺优达基因科技（北京）有限公司
崔丽娜 (2016届博士) 安诺优达基因科技（北京）有限公司
黄  幸 (2016届硕士) 滨松光子学商贸（中国）有限公司（Hamamatsu Photonics (China) Ctd.）
范  强 (2017届硕士) 清华大学，在读博士
伊培烨 (2018届硕士) 安诺优达基因科技（北京）有限公司
崔  航 (2019届硕士) 中国通用技术集团
马  骄 (2019届博士) 北京大学附属第三医院
郭珊珊 (2020届博士) 河南工业大学
于偌萱 (2020届博士) 宜康生物技术有限公司
蒋祥祥 (2021届博士后) 安徽医科大学；教授
刘亚伟 (2021届博士后) 苏州市独墅湖医院（苏州大学附属独墅湖医院）
王一名 (2022届博士) 北京大橡科技有限公司

联合培养学生
林　平 (2008届博士) 现在哈尔滨医科大学
周　莹 (2010届硕士) 现在北京市中关村医院
王青欣 (2011届硕士) 首都医科大学附属北京妇产医院
张　倩 (2012届博士) 重庆医科大学
李巍巍 (2014届博士) 北京师范大学
李  悦 (2015届博士) 哈尔滨医科大学
聂明月 (2015届硕士) 首都医科大学附属北京妇产医院
李　敏 (2016届博士) 中国人民解放军总医院（301医院）
何于夏 (2016届博士) 南方医科大学
方　颖 (2016届硕士) 首都医科大学附属北京妇产医院
杨　萌 (2017届硕士) 安徽大学
洪黎明 (2019届博士) 首都医科大学附属北京妇产医院
赵飞燕 (2022届博士) 首都医科大学附属北京朝阳医院
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