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王红梅实验室

个人介绍 | 承担项目 | 发表论文 | 其它方面介绍 | 实验平台 | 学生和其他工作人员 | 学术和业余活动照片 | 人才培养

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个人介绍

　　王红梅，博士，研究员，博士生导师；中国科学院动物研究所干细胞与生殖生物学国家重点实验室主任，北京干细胞与再生医学研究院副院长。国家杰出青年基金获得者，万人计划领军人才，国家百千万人才工程 “有突出贡献中青年专家”，国家自然科学基金重大项目负责人，国家重点研发计划“基于干细胞的生育力维持与重建”项目负责人。
　　1995年于北京师范大学生物系获得学士学位，2002年于中国科学院动物研究所获得理学博士学位，2003-2005年在加拿大渥太华健康研究所从事博士后研究。王红梅课题组研究方向包括：（1）哺乳动物早期胚胎和胎盘发育；（2）干细胞与生育力的维持和重建。曾获谈家桢生命科学创新奖，全国妇幼健康科学技术奖一等奖及中国科学院优秀导师奖、“朱李月华优秀教师奖”、“领雁银奖、振翅奖”等。培养的研究生获得中华人民共和国教育部硕士/博士研究生国家奖学金；中国科学院院长特别奖；中国科学院大学三好学生、优秀毕业生等荣誉称号。目前担任Cell Proliferation、Cell Reports Medicine、Biology of Reproduction、Reproduction、Fundamental Research、生物医学转化、动物学杂志期刊副主编或编委，在Science、Nature、Cell、Nature Genetics、Nature Nanotechnology等期刊发表论文80余篇，相关工作被Science亮点评价、在Nature网页头条报道、登上Cell期刊封面。受邀在Gordon、Keystone等国际学术会议做报告。

发表论文

  1. Yu D#, Wan H#, Tong C#, Guang L#, Chen G#, Su J#, Zhang L, Wang Y, Xiao Z, Zhai J, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W*, Qi H*, Wang H*, Shyh-Chang N*. A multi-tissue metabolome atlas reveals core signatures and critical nodes of metabolic reprogramming in female primates during pregnancy. Cell. 2024, 187, 764-781 e714.
  2. Wang M#, Liu Y#, Sun R#, Liu F#, Li J, Yan L, Zhang J, Xie X, Li D, Wang Y, Li S, Zhu X, Li R*, Lu F*, Xiao Z*, Wang H*. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. Nat Genet. 2024, 56, 294-305.
  3. Zhao F#, Yan L#, Zhao X#, Wu J#, Fang Y, Xin Z, Wang H*, Yang X*. Aberrantly high FBXO31 impairs oocyte quality in premature ovarian insufficiency. Aging and Disease. 2024, 15(2):1-20.
  4. Wang Y#, Deng W#, Lee D#, Yan L#, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H*, Kim BYS*, Jiang W*. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nat Nanotechnol. 2024,19, 255-263.
  5. Xia S#, Yu D#, Wang Y, He B, Rong Y, Chen R, Xiao Z, Wang H, Wu H*, Yan L*. ISRIB facilitates the co-culture of human trophoblast stem cells and embryonic stem cells. Cell Proliferation. 2023.
  6. Wang M, Liu Y, Xiao Z（通讯作者）, et al. Technical Specifications for Ethics Review of Human Stem cell Research. Cell Proliff. 2023. 已接收
  7. Wu X#, Zhai J#, Li Q#, Wang H*. The in vitro culture of mammalian embryos. Nat Method.2023, 20, 1855-1858. (comments)
  8. Wu H#, Huang XY#, Sun MX#, Wang Y#, Zhou HY#, Tian Y#, He BJ, Wu AP, Wang H*, Qin CF*. Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids. Nat Commun. 2023, 14, 5541.
  9. Wu X#, Zhao W#, Wu H#, Zhang Q#, Wang Y, Yu K, Zhai J, Mo F, Wang M, Li S, Zhu X, Liang X, Hu B, Liu GH, Wu J##, Wang H##, Guo F*, Yu L*. An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Prolif. 2023, e13492.（##, Senior author）
  10. Wu H#, Luo CX#, Rong Y, Yu RX, Zhao Y, Yan L*, Wang H*, Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level. Life Medicine. 2023.
  11. Zhai J#, Xu Y#, Wan H#, Yan R#, Guo J#, Skory R#, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W*, Guo F*, Plachta N*, Wang H*. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell. 2023 May, 186(10), 2078-2091.e18. (cover story)
  12. Jiang X #, Zhai J #, Xiao Z#, Wu X#, Zhang D#, Wan H, Xu Y, Qi L, Wang M, Yu D, Liu Y, Wu H, Sun R, Xia S, Yu K, Guo J, Wang H*. Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta spanning during pregnancy at single-cell resolution. Dev Cell. 2023 Apr, 58, 806-821.
  13. Jiang X#*, Wang Y#, Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X*, Wang H*. A differentiation roadmap of murine placentation at single-cell resolution. Cell Discov. 2023 Mar, 9(1), 30.
  14. Wu H#, Wang Y#, Wang H*. Generation of Human Trophoblast Stem Cell-Dependent Placental In Vitro Models. Methods Mol Biol. 2022 Dec. (book chapter)
  15. Wu H#, Wang Y#, Wang H*. Workflow for Performing Genetic Manipulation in Human Trophoblast Stem Cells Using CRISPR/Cas9 Technology. Methods Mol Biol. 2022 Dec. (book chapter)
  16. Zhai J#, Guo J#, Wan H#, Qi L#, Liu L#, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X*, Guo F*, Wu J*, Wang H*. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022 Dec, 612(7941), 732-738.
  17. Zhou JJ#, Jiang XX#, Wu HW#, Zhang LJ, Chen M, Chen M, Shen ZM, Guo XD*, Wang H*, Gao F*, Dissecting the fate of 1 Foxl2-expressing cells in fetal ovary using lineage tracing and Single-Cell Transcriptomics. Cell Discov. 2022 Dec, 8(1), 139.
  18. Yan R#, Cheng X#, Gu C#, Xu YH#, Long X#, Zhai JL, Sun FY, Qian JJ, Du YR, Wang H*, Guo F*, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023 Jan, 55(1), 130-143.
  19. Ma J#, Liu Y#, Guo Z#, Sun R#, Yang X, Zheng W, Ma Y, Rong Y, Wang H*, Yang H*, Xiao Z*. The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing. Front Cell Dev Biol. 2022 Nov, 10, 1044198.
  20. Gu Z#, Guo J#, Zhai J#, Feng G, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L,Hua H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S,* Wang H*, Gu Q*. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci (Weinh). 2022 Oct, 9(28), e2202282.
  21. Tu W#, Ni D#, Yang H#, Zhao F#, Yang C#, Zhao X#, Guo Z#, Yu K, Wang J, Hu Z, Chen Z, Zhao Y, Wang Z, Gao F, Yan L*, Yang X*, Zhu L*, Wang H*. Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study. Sci Bull. 2022 Sep, 67(18), 1854-1859.
  22. Li Q#, Wu H#, Wang Y#, Wang H*, Current understanding in deciphering trophoblast cell differentiation during human placentation. Biol Reprod. 2022 Jul, 107(1), 317-326. (Review)
  23. Wang Y#, Jiang X#, Jia L#, Wu X#, Wu H#, Wang Y, Li Q, Yu R, Wang H*, Xiao Z*, Liang X*. A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization. Front Cell Dev Biol. 2022 Jun, 10, 835445.
  24. Wang Y#, Wu H#, Jiang X#, Jia L#, Wang M, Rong Y, Chen S, Wang Y, Xiao Z*, Liang X*, Wang H*. LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells. Front Cell Dev Biol. 2022 Apr, 10, 836390.
  25. Zhai J#, Xiao Z#, Wang Y#, Wang H*. Human embryonic development: from peri-implantation to gastrulation. Trends Cell Biol. 2022 Jan, 32(1), 18-29. (Review)
  26. Liang G#, Zhou C#, Jiang X#, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B*, Wang H*, Han JJ*, Liu F*. De novo generation of macrophage from placenta-derived hemogenic endothelium. Dev Cell. 2021 Jul, 56(14), 2121-2133.
  27. Wu H#, Liao S#*, Wang Y#, Guo M#, Lin X, Wu J, Wang R, Lv D, Wu D, He M, Hu B, Long R, Peng J, Yang H, Yin H, Wang X, Huang Z, Lan K, Zhou Y, Zhang W, Xiao Z, Zhao Y*, Deng D*, Wang H*. Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19. Cell Prolif. 2021 Sep, 54(9), e13091.
  28. Yan R#, Gu C#*, You D, Huang Z, Qian J, Yang Q, Cheng X, Zhang L##, Wang H##, Wang P*, Guo F*. Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing. Cell Stem Cell. 2021 Sep, 28(9), 1641-1656.e7.（##, Senior author）
  29. Li X#, Wang Y#, Ma R#, Liu X, Song B, Duan Y, Guo J, Feng G, Cui T, Wang L, Hao J*, Wang H*, Gu Q*. Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCsin vivoandin vitro. Biomed Mater. 2021 Mar, 16(3), 035023.
  30. Qu Y#, Chen Q#, Guo S#, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan *E, Zhang Y*, Wang H*. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein Cell. 2021 Oct, 12(10), 810-817. (Letter)
  31. Cui D#, Liu Y#, Jiang X#, Ding C, Poon LC*, Wang H*, Yang H*. Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta. Ultrasound Obstet Gynecol. 2021 Feb, 57(2), 248-256.
  32. Zhao Y#, Ma J#, Yi P#, Wu J#, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J*, Wang H*, Yan L*. Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice. Stem Cell Res Ther. 2020 Nov, 11(1), 466.
  33. Yan L#, Wu Y#, Li L#, Wu J#, Zhao F, Gao Z, Liu W, Li T, Fan Y*, Hao J*, Liu J*, Wang H*. Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Prolif. 2020 Dec, 53(12), e12938.
  34. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Curr Opin Cell Biol. 2020 Dec, 67, 86-91. (invited review)
  35. Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N*. Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020 Sep, 585(7825), 404-409.
  36. Gao H, Liu C, Wu B, Cui H, Zhao Y, Duan Y, Gao F*, Gu Q*, Wang H*, and Li W*. Effects of Different Biomaterials and Cellular Status on Testicular Cell Self-Organization. Adv Biosyst. 2020 Jul, 4(7), e1900292.
  37. Jiang X*, Wang H*. Macrophage subsets at the maternal-fetal interface. Cell Mol Immunol. 2020 Aug, 17(8), 889-891.
  38. Ma H#, Zhai J#, Wan H#, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019, 366(6467).
  39. Guo S#, Cui X#, Jiang X#, Duo S, Li S, Gao F*, Wang H*. Tracing the origin of the placental trophoblast cells in mouse embryo development. Biol Reprod. 2020 Mar, 102(3), 598-606.
  40. Wang R#, Yu R#, Zhu C, Lin HY, Lu X*, Wang H*. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019 Dec, 11(11), 967-978. (cover story)
  41. Hong L#, Yan L#, Xin Z, Hao J, Liu W, Wang S, Liao S, Wang H*, Yang X*. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2020 Jun, 12(5), 372-385.
  42. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic plate under serum-free condition. Stem Cell Res Ther. 2019 Jan, 10(1), 19.
  43. Jiang Y#, Yan L#, Xia L, Lu X, Zhu W, Ding D, Du M, Zhang D, Wang H*, Hu B*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem. 2018 Dec, 293(50), 19317-19329 .
  44. Wang Y, Wang H*. Successful derivation of human trophoblast stem cells. Biol Reprod. 2018 Aug, 99(2), 271-272. (research highlight)
  45. Liu Y#, Fan X#, Wang R#, Lu X#, Dang YL, Wang H, Lin HY, Zhu C, Ge H, Cross JC*, Wang H* Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 2018 Aug, 28(8), 819-832.
  46. Jiang X, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cell Mol Immunol. 2018 Dec, 15(12), 1027-1037.
  47. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu H, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng W*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018 Jan, 145(2), dev148932.
  48. Lu X#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Rep. 2017 Oct, 21(5), 1150-1159.
  49. Yan L#, Li Y#, Shi Z#, Lu X#, Ma J, Hu B, Jiao J*, Wang H*. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem. 2017 Aug, 292(31), 12959-12970.
  50. Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017 Jun, (6), e26248.
  51. Zhang Y#, Wang Q#, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends in Molecular Medicine. 2017, 23(7), 604–614. (invited review)
  52. 王红梅*，杜美蓉*.人类胎盘滋养层细胞的分化与妊娠相关疾病. 生命科学. 2017, 29(1), 15-20.
  53. Liu D#, Mo G#, Tao Y, Wang H*, Liu XJ*. Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts. Reprod Fertil Dev. 2017 Jul, 29(7), 1392-1400.
  54. Lu X#, Wang Y#, Yan L, Wang L, Li W, Wang H*. Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs. J Genet Genomics. 2016 Oct, 43(10), 609-612.
  55. Cui L#, Wang H#, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Migr. 2016 Mar, 10(1-2), 39-55.
  56. Nie M#, Yu S#, Peng S, Fang Y, Wang H*, Yang X*. miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5. Biol Reprod. 2015 Oct, 93(4), 98, 1-10.
  57. Zhang Q#, Yu S#, Huang X#, Tan Y, Zhu C, Wang Y, Wang H, Lin H, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 2015 Aug, 150(2), 139-149.
  58. Li Y, Zheng R, Wang R, Lu X, Zhu C, Lin HY, Wang H, Yu X*, Fu J*. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction. 2015 Apr, 149(4), 339-46.
  59. Lei JH#, Yang X#, Peng S#, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab. 2015 May, 100(5), 1819-27.
  60. Chang WL#, Yang Q#, Zhang H#, Lin HY, Zhou Z, Lu X, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction. 2014 Oct, 148(4), 343-352.
  61. Zhou Z#, Wang R#, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta. 2014 Nov, 35(11), 907-18. Placenta.
  62. Wang R#, Dang YL#, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod. 2014 Jun, 90(6), 117, 1-10 (cover story).
  63. Li W, Liu D, Chang W, Lu X, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis. 2014 Jan, 5(1), e1025.
  64. Aguilar PS#, Baylies MK#, Fleissner A#, Helming L#, Inoue N#, Podbilewicz B*, Wang H#, Wong M#. Genetic basis of cell–cell fusion mechanisms. Trends Genet. 2013 Jul, 29(7), 427-437. (#, equal contribution.) (invited review)
  65. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis. 2013 Apr, 4(4), e593.
  66. Zhang S, Lin HY#, Kong S#, Wang S, Wang Hongmei, Wang Haibin*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 2013 Oct, 34(5), 939-980. (#, co-first authors.)
  67. Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis. 2013 Feb, 4(2), e502.
  68. Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W*, Wang H*. Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. PLoS One. 2013, 8(2), e50479.
  69. Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab. 2012 Apr, 97(4), E678-E686.
  70. Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem. 2012 Oct, 113(10), 3266-3275.
  71. Wu L, Zhou H, Lin H, Qi J, Zhu C, Gao Z*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction. 2012 Mar, 143(3), 389-397.
  72. Yang X, Zhou Y, Peng S, Wu L, Lin HY, Wang S*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction. 2012 Aug, 144(2), 235-244.
  73. Lin P, Fu J, Zhao B, Lin F, Zou H, Liu L, Zhu C, Wang H*, Yu X*. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol Biol Rep. 2011 Mar, 38(3), 1741–1747.
  74. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem. 2010 Apr, 285(14), 10870-10879.
  75. Zhang B, Zhou Z, Lin H, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol. 2009 Aug, 132(2), 169-179.
  76. Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta. 2009 Nov, 30(11), 929-938.
  77. Fu JJ, Lin P, Lv XY, Yan XJ, Wang HX, Zhu C, Tsang BK, Yu XG*, Wang H*. Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion. Placenta, 2009 Apr, 30(4), 305-312.
  78. Wang H*, Tsang BK*. Nodal signalling and apoptosis. Reproduction. 2007 May, 133(5), 847-853.
  79. Zhang X, Zhu C, Lin H, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod. 2007 Aug, 77(2), 358-364. (cover srory)
  80. Wang H*, Jiang JY, Zhu C, Peng C, Tsang BK*. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol Endocrinol. 2006 Oct, 20(10), 2469-82.

 

其它方面介绍

主要学习经历：

  • 1999.09～2002.06 中国科学院动物研究所生理学博士
  • 1995.09～1998.07 北京师范大学生物系细胞生物学硕士
  • 1991.09～1995.07 北京师范大学生物系生物学学士

主要工作经历：

  • 2021.12～ 北京干细胞与再生医学研究院 副院长
  • 2017.05～ 干细胞与生殖生物学国家重点实验室主任
  • 2013.01～2017.05 干细胞与生殖生物学国家重点实验室副主任
  • 2013.01～2020.09 干细胞与生殖生物学国家重点实验室党总支书记
  • 2006.09～ 干细胞与生殖生物学国家重点实验室研究员、博士生导师、生殖生理学研究组组长
  • 2003.12～2005.12 加拿大渥太华健康研究所(OHRI)博士后
  • 2003.01～2006.09计划生育生殖生物学国家重点实验室 副研究员
  • 2002.01～2002.12计划生育生殖生物学国家重点实验室 助理研究员
  • 1998.07～2002.01 中国科学院动物研究所计划生育生殖生物学国家重点实验室 研究实习员

社会任职：

  • Centre for Trophoblast Research Scientific Advisory Board委员 （2023-）
  • Reproduction 副主编 （2023-）
  • Cell Reports Medicine编委（2020-）
  • Cell Proliferation 编委（2018-）
  • Biology of Reproduction 编委（2013-）
  • 动物学杂志 第十三届编辑委员会副主编（2021）
  • Fundamental Research（双月刊） 编委（2021.01-2023.12）
  • 生物医学转化 第一届编委会委员（2020-）
  • 中国动物学会生殖生物学分会 主任委员（2019-）
  • 妇幼健康研究会母胎医学专业委员会 常务委员（2016-）
  • 中国生物物理学会女科学家分会（BSC女科学家分会）副秘书长（2021-）
  • 中国生理学会生殖科学专业委员会（第24届） 委员（2016-）
  • 中国医师协会整合医学医师分会 整合医学生殖医学专业委员会(学组) 第一届委员会 副主任委员（2017-）
  • 美国生殖生物学学会（SSR）会员（2001-）
  • 国际干细胞学会（ISSCR）会员（2021-）

获奖及荣誉：

  • 2023年入选“中国生命科学十大进展”。
  • 2023年谈家桢生命科学创新奖。
  • 2023年获中国细胞生物学学会干细胞生物学分会，干细胞研究创新科学家奖。
  • 2023年第五届妇幼健康科学技术奖自然科学奖一等奖：（2023-Z-F-7-01）早期胚胎发育与不良妊娠结局；
  • 2023年中国实验动物学会科学技术奖一等奖：（20201004-1-P1403）利用ENU诱变方法大规模创制小型猪突变模型；
  • 2017年全国妇幼健康科学技术奖二等奖：（自然科学奖，2017-B-F-04-03）微小RNA对卵泡生长发育的调控及其在卵巢早衰中的作用研究；
  • 2017年全国妇幼健康科学技术奖二等奖：（自然科学奖，2017-B-D-01-02）母胎免疫耐受与排斥（流产）转换的分子机理；
  • 2011年国家人口和计划生育委员会优秀科技成果奖一等奖（2011-01-D01）胚胎植入的分子基础与相关疾病；
  • 2008年教育部高等学校科学研究优秀成果奖（科学技术）二等奖（自然科学类）蝙蝠的行为、进化及其与病毒相互关系的研究；
  • 2021年中国科学院大学教学科研工作“领雁银奖、振翅奖”；
  • 2020年“中国科学院朱李月华优秀教师奖”；
  • 2020年度中国科学院优秀导师奖；

学生和其他工作人员

学术和业余活动照片

人才培养

张晓萍 (2007届博士) 美国俄亥俄州立大学 (Ohio State University)
付杰军 (2008届博士) 美国芭芭拉．安卡马纳司癌症中心(The Barbara Ann Karmanos Cancer Institute, Detroit, USA)，现在广西医科大学
张保华 (2009届博士) 加拿大渥太华大学健康研究所 (University of Ottawa)
李　闯 (2010届硕士) 攻读博士学位
周　智 (2011届博士) 日本国立遗传学研究所 (Mammalian Development Laboratory, National Institute of Genetics)
吴　亮 (2011届博士) 浙江大学；博士后
赵坤庆 (2012届博士) 北京生命科学院；博士后
王  蕊 (2015届博士) MD安德森癌症中心（The University of Texas MD Anderson Cancer Center）
吕晓寅（2015届博士）MD安德森癌症中心（The University of Texas MD Anderson Cancer Center）
刘丹丹 (2015届博士) 北京大学第三医院；博士后
刘素梅 (2014届硕士) 中国科学院遗传与发育生物学研究所
郑  茹 (2017届博士) 安诺优达基因科技（北京）有限公司
崔丽娜 (2016届博士) 安诺优达基因科技（北京）有限公司
黄  幸 (2016届硕士) 滨松光子学商贸（中国）有限公司（Hamamatsu Photonics (China) Ctd.）
范  强 (2017届硕士) 清华大学，在读博士
伊培烨 (2018届硕士) 安诺优达基因科技（北京）有限公司
崔  航 (2019届硕士) 中国通用技术集团
马  骄 (2019届博士) 北京大学附属第三医院
郭珊珊 (2020届博士) 河南工业大学
于偌萱 (2020届博士) 宜康生物技术有限公司
蒋祥祥 (2021届博士后) 安徽医科大学；教授
刘亚伟 (2021届博士后) 苏州市独墅湖医院（苏州大学附属独墅湖医院）
王一名 (2022届博士) 北京大橡科技有限公司

联合培养学生
林　平 (2008届博士) 现在哈尔滨医科大学
周　莹 (2010届硕士) 现在北京市中关村医院
王青欣 (2011届硕士) 首都医科大学附属北京妇产医院
张　倩 (2012届博士) 重庆医科大学
李巍巍 (2014届博士) 北京师范大学
李  悦 (2015届博士) 哈尔滨医科大学
聂明月 (2015届硕士) 首都医科大学附属北京妇产医院
李　敏 (2016届博士) 中国人民解放军总医院（301医院）
何于夏 (2016届博士) 南方医科大学
方　颖 (2016届硕士) 首都医科大学附属北京妇产医院
杨　萌 (2017届硕士) 安徽大学
洪黎明 (2019届博士) 首都医科大学附属北京妇产医院
赵飞燕 (2022届博士) 首都医科大学附属北京朝阳医院
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